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Creative Biolabs Expands Bispecific Antibody Functional Analysis Services

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Creative Biolabs Expands Bispecific Antibody Functional Analysis Services

March 02
21:50 2020

New York, USA – Creative Biolabs, an antibody expert engaged in antibody development field for over 10 years, has recently expanded bispecific antibody functional analysis services to cover different client needs, which include bispecific antibody (bsAb) Affinity Measurement, Antibody-dependent Cell-mediated Cytotoxicity (ADCC) Assay, Complement-dependent Cytotoxicity (CDC) Assay, and Antibody-dependent Cellular Phagocytosis (ADCP) Assay.

1. BsAb Affinity Measurement

A high-quality bsAb is supposed to be equipped with high affinity to better target and enhance effects. For the sake of a complete affinity measurement, Creative Biolabs offers three professional technologies, 1) Surface Plasmon Resonance (SPR) to measure the kinetics and binding affinities of ligand binding interactions, 2) ELISA-based Assay to determine serum antibody concentrations and antigen-antibody interactions, 3) Flow Cytometry Assay to massively analyze the physical and chemical characters of tons of particles per second.

2. BsAb Antibody-dependent Cell-mediated Cytotoxicity (ADCC) Assay

ADCC is a convenient and accurate tool to examine the in vivo efficacy of antibody candidates. At Creative Biolabs, technicians design a series of ADCC assays in compliance with strict standards, by organizing different effector cells, such as peripheral blood mononuclear cells (PBMCs) and natural killer (NK) cells, and adopting effective methods, such as the 51Cr approach and LDH approach.

3. BsAb Complement-dependent Cytotoxicity (CDC) Assay

Creative Biolabs offers highly reproducible NK cell complement-dependent cytotoxicity (CDC) assays to quickly evaluate the cytotoxicity profile through a high throughput way. Technicians are capable of performing CDC assays through radioactive and non-radioactive methods. The former one determines the efficacy to mediate cell death by the radioactivity while the latter one determines the release of abundant cell components.

4. BsAb Antibody-dependent Cellular Phagocytosis (ADCP) Assay

The comprehensive antibody analysis platform from Creative Biolabs enables high-quality BsAb antibody-dependent cellularphagocytosis (ADCP) assays. A reporter-gene assay is provided for a fast and accurate measurement, in which primary monocytes are taken place with an engineered reporter cell line stably expressing FcγRⅡa (H131) and NFAT-RE/luc2.

“We are committed to providing our global clients with time-saving and low-cost services. Our years of efforts have earned our company a good reputation in this industry. We insist that a good CRO should take each specific requirement into account. Therefore, our scientists are trained to detailedly customize every project in terms of what clients need,” introduced by the manager at Creative Biolabs.

More information on bispecific antibody services and products can be found at https://www.creative-biolabs.com/bsab.

About Creative Biolabs

Creative Biolabs was established in 2004 by scientists who are dedicated to conquering of cancer. Over the past 10 years, Creative Biolabs has grown into a recognized world leader in antibody (rAb) discovery, engineering, production, and analysis. Standing on the shoulder of a giant, the bispecific antibody (BsAb) team has a collective of experienced scientists committed to providing high-quality services to customers all over the world. Now, with the cutting-edge platforms and methods (quadroma development, chemical conjugation, and genetic engineering), a comprehensive list of bispecific antibody products is available to customers in academia and industry fields.

Media Contact
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
Phone: 1-631-619-7922
Country: United States
Website: https://www.creative-biolabs.com/bsab

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